Improved protocols for histamine sensitization testing of acellular pertussis vaccines
H Oh, J Joung, BG Kim, KT Nam, SH Hong, HC Song… - Vaccine, 2012 - Elsevier
The histamine sensitization test is a widely used method for measuring the residual toxicity
of pertussis toxin in acellular pertussis vaccines. Although it has been used as a routine
assay for decades, the current protocols are difficult to standardize because the test results
vary considerably and are based on several factors, including mouse strain, age and sex. In
this study, we observed that mice of strains CD1, ddY and C57/BL6 were sufficiently
sensitive to pertussis toxin among six mice strains tested and that aged male mice were …
of pertussis toxin in acellular pertussis vaccines. Although it has been used as a routine
assay for decades, the current protocols are difficult to standardize because the test results
vary considerably and are based on several factors, including mouse strain, age and sex. In
this study, we observed that mice of strains CD1, ddY and C57/BL6 were sufficiently
sensitive to pertussis toxin among six mice strains tested and that aged male mice were …
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